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Mast Cells And Microscopic Colitis
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Site Admin
Site Admin

Joined: 24 May 2005

Posts: 31093
User's local time:
2018 Feb 18 - 11:44 PM

Food Intolerances : Gluten, casein, soy, and avenin, (avenin is the prolamin in oats, which is equivalent to the gluten in wheat), beef, grapes, peanuts, cashews, almonds, (but nut butters seem OK except for peanuts), citric acid, chocolate, and agar.
Location: Central Texas

PostPosted: Tue Mar 14, 2017 5:29 pm    Post subject: Reply with quote

Yes, in my opinion if antihistamines help then that's pretty strong evidence of MCAD or some other mast cell issue.

It might be necessary to continue to take an antihistamine for a month or so, but the first line of treatment should be to reduce the amount of high-histamine foods in the diet. That can be done in 2 different ways

1. simply don't eat high-histamine foods, or at least minimize the amount.

2. treat high-histamine foods differently in order to prevent them from from becoming high-histamine foods. Some foods are always high-histamine (fermented, dried, or smoked foods for example), but some foods are not high-histamine when purchased they develop high-histamine levels by improper handling (chicken, fish, bananas and other fruit, for example).


It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
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Emperor Penguin
Emperor Penguin

Joined: 21 Dec 2009

Posts: 7379
User's local time:
2018 Feb 19 - 3:44 PM

Food Intolerances : Gluten, Yeast, Caesin, Soy, salad/raw veges and fruit
Location: Hunter Valley NSW Australia

PostPosted: Tue Mar 14, 2017 6:01 pm    Post subject: Reply with quote

Further to Tex's suggestions above, the other two key things to resolving histamine/mast cell issues

- magnesium (there are published studies supporting this)
- resolving B6 imbalances - ideally via active form of P5P

magnesium and right levels of B6 allow the body to 'manage' histamine levels. ie treats the root cause of the issue.
long term our bodies need small amounts of histamine. so long term use of antihistamines that totally block histamine is not ideal.
Gabes Ryan

"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
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Rockhopper Penguin
Rockhopper Penguin

Joined: 28 Nov 2011

Posts: 958
User's local time:
2018 Feb 18 - 11:44 PM

Food Intolerances : Gluten, Casein
Location: Wisconsin

PostPosted: Tue Mar 14, 2017 8:16 pm    Post subject: Reply with quote

Thank you very much Tex and Gabes for clarifying this more for me. It makes more sense to treat mast cell issues by reducing the intake of high histamine foods. I continue to be amazed how important magnesium is!

When I started "trying" to understand mast cell issues, I only got to the point of trying H1 antihistamines for a few weeks to see if I would notice improvements on my D. In my case no improvements were seen, so I discontinued taking them. After that I didn't read much further on the topic as I believed I did not have mast cell issues to the extent that it required attention. I then focused my research on other areas I had to work on.

Again, thank you both for your help.

"You'll never know how strong you are until being strong is the only choice you have."

"Life is not about waiting for the storm to pass... It's learning to dance in the rain."
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